BEYOND GAP JUNCTION CHANNEL FUNCTION: THE EXPRESSION OF CX43 CONTRIBUTES TO ALDOSTERONE-INDUCED MESANGIAL CELL PROLIFERATION VIA THE ERK1/2 AND PKC PATHWAYS

Aims: This study aimed to explore the precise mechanism and signaling pathways of mesangial cell (MC) proliferation from a new point of view considering Connexin 43 (Cx43).Methods: MC proliferation was measured by the incorporation of 3H-thymidine (3H-TdR).Cx43 was over-expressed in MC cells using lipofectamine 2000, and the expression level was te

Abstract Emulsifiers are responsible for forming a dough that contributes to the retention of gluten in alveoli, the gas produced by the yeast, thus increasing the volume and softness of the bread.There are indications that hydrocolloids, such as taro mucilage (Colocasia esculenta), can present similar characteristics to emulsifiers.The presence of

Summary: Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive fibrosis and hypovascularization, resulting in significant intratumoral hypoxia (low oxygen) that contributes to its aggressiveness, therapeutic resistance, and high mortality.Despite oxygen being a fundamental requirement for many cellular and metabolic processes, and t

During winter insects face energetic stress driven by lack of food, and thermal stress due to sub-optimal and even lethal temperatures.To survive, most insects living in seasonal environments such as high latitudes, enter diapause, a deep resting stage characterized by a cessation of development, metabolic suppression and increased stress tolerance